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Listar por autor "Calvo Baltanás, Fernando"
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Artículo
Critical Requirement of SOS1 for Development of BCR/ABL-Driven Chronic Myelogenous Leukemia
Gómez Rodríguez, Carmela; García Navas, Rósula; Calvo Baltanás, Fernando; Fuentes Mateos, Rocío; Fernández Medarde, Alberto; Calzada, Nuria; Santos, Eugenio (MDPI, 2022-08-11)We showed previously that the ABL-mediated phosphorylation of SOS1 promotes RAC activation and contributes to BCR-ABL ...
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Artículo
Critical requirement of SOS1 RAS-GEF function for mitochondrial dynamics, metabolism, and redox homeostasis
García Navas, Rósula; Liceras Boillos, Pilar; Gómez Rodríguez, Carmela; Calvo Baltanás, Fernando; Calzada, Nuria; Nuevo Tapioles, Cristina; Cuezva Marcos, Jose Manuel; Santos, Eugenio (Nature Publishing Group, 2021-06-12)SOS1 ablation causes specific defective phenotypes in MEFs including increased levels of intracellular ROS. We showed that ...
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Artículo
Functional Specificity of the Members of the Sos Family of Ras-GEF Activators: Novel Role of Sos2 in Control of Epidermal Stem Cell Homeostasis
Mucientes Valdivieso, Cynthia; Lorenzo Martín, Luis Francisco; Fernández Parejo, Natalia; García Navas, Rósula; Segrelles, Carmen; Calzada, Nuria; Fuentes Mateos, Rocío; Paramio, Jesús M.; Bustelo, Xosé R.; Santos, Eugenio; Calvo Baltanás, Fernando (MDPI, 2021-04-29)Prior reports showed the critical requirement of Sos1 for epithelial carcinogenesis, but the specific functionalities of ...
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Trabajo Fin de Grado
Propuesta de entrenamiento para paliar las consecuencias del tratamiento ante diferentes tipos de cáncer de mama y leucemia infantil.
Holgado Villena, Luis (2022)En este proyecto hemos llevado a cabo una revisión de las principales guías sobre ejercicio para el paciente ...
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Artículo
SOS GEFs in health and disease
Calvo Baltanás, Fernando; Zarich, N; Rojas-Cabaneros, JM; Santos, E (Elsevier, 2020)SOS1 and SOS2 are the most universal and widely expressed family of guanine exchange factors (GEFs) capable or activating ...
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Artículo
SOS2 Comes to the Fore: Differential Functionalities in Physiology and Pathology
Calvo Baltanás, Fernando; García Navas, Rósula; Santos, Eugenio (MDPI, 2021-06-21)The SOS family of Ras-GEFs encompasses two highly homologous and widely expressed members, SOS1 and SOS2. Despite their ...
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Artículo
The Childhood-Onset Neurodegeneration with Cerebellar Atrophy (CONDCA) Disease Caused by AGTPBP1 Gene Mutations: The Purkinje Cell Degeneration Mouse as an Animal Model for the Study of this Human Disease
Calvo Baltanás, Fernando; Berciano, María T.; Santos, Eugenio; Lafarga, Miguel (MDPI, 2021-09-04)Recent reports have identified rare, biallelic damaging variants of the AGTPBP1 gene that cause a novel and documented ...